University of Michigan Scientists Have Found that Bone Marrow Can Harbor HIV-Infected Cells
Tuesday, March 9, 2010 at 11:27AM The Science Daily News reported that University of Michigan scientists have identified a new reservoir for hidden HIV-infected cells that can serve as a factory for new infections. The findings, which appeared online March 7 in Nature Medicine, indicate a new target for curing the disease so those infected with the virus may someday no longer rely on AIDS drugs for a lifetime.
"Antiviral drugs have been effective at keeping the virus at bay. However once the drug therapy is stopped, the virus comes back," says senior author of the study Kathleen L. Collins, M.D., Ph.D., associate professor of both internal medicine and microbiology and immunology at the U-M Medical School.
"Our finding that HIV infects these cells has clear ramifications for HIV disease because some of these cells may be long-lived and could carry latent HIV for extended periods of time," she says. "These HIV cell reservoirs can be induced to generate new infections."
A new sixth edition of the best-selling book, AIDS: Science and Society (Jones and Bartlett, 2011) by Hung Fan, Ross Conner, and Luis Villarreal, all from University of California - Irvine, provides readers with a solid overview of AIDS from both a biomedical and a psychosocial perspective. The authors cover the molecular and cellular aspects of the virus and the immune system's response to it, and examine epidemiology and its role in understanding HIV and AIDS.
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